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KMID : 0615720140310020119
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Jouranl of Korean Acupuncture and Moxibustion society
2014 Volume.31 No. 2 p.119 ~ p.134
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Inhibitory Effects of Filiform Acupuncture and Laser Acupuncture at the Points of Zhongzhu(TE3)·Zulinqi(GB41) on Neuropathic Pain in the Tibial and Sural Nerve Injury-induced Rats
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Lee Ju-Hee
Lee Dong-Geun
Lee Ook-Jae
Lee Sang-Hyun
Lee Jung-Hun
Jeong Joo-Yong
Cheong Min-Seong
Yang Tae-Jun
Kim Seon-Wook
Cho Myoung-Rae
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Abstract
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Objectives: The purpose of this study was to investigate the analgesic effects of filiform acupuncture and laser acupuncture at the points of TE3·GB41 in neuropathic pain induced rats.
Methods: Neuropathic pain in rats was induced by partial resection of the tibial and sural nerves. Three weeks after the neuropathic surgery, each of the experimental groups(AT, LAT, AT + LAT and LAT + AT) was injected at the TE3·GB41 twice per week for three weeks.
Results:
1.All of the experimental groups(AT, LAT, AT + LAT and LAT + AT) showed a significant decrease in the plantar withdrawal response of allodynia and the thermal allodynia as compared with the control group. During the early phase, the AT and AT + LAT groups have been marked as more significant than the LAT + AT and LAT groups.
2.The expression of c-Fos significantly decreased in the LAT and LAT + AT groups as compared with the control group.
3.The LAT + AT group showed a significant decrease in Bax as compared with the control group. In each experimental groups(AT, LAT, AT + LAT and LAT + AT), Bcl-2 increased and Bax/Bcl-2 ratio decreased as compared with the control group.
4.The LAT, AT + LAT and LAT + AT groups showed a significant increase in mGluR5 as compared with the control group.
Conclusions: These results represented that the filiform acupuncture and laser acupuncture at the TE3·GB41 exerted anti-apoptotic and neuroprotective effects on the model of neuropathic pain, thereby suggesting that they should be available for decreasing mechanical allodynia.
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KEYWORD
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Zhongzhu (TE3), Zulinqi (GB41), Neuropathic pain, Acupuncture, Laser acupuncture
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